Gemeprost ( 16,16 -dimethyl-trans-delta2 PGE 1 methyl ester) is an analogous structure of prostaglandin E 1 .

Clinical use

The gemeprost is used in:

  • Obstetric haemorrhage .
  • Abortion with medication . Gemeprost is used as an alternative to misoprostol along with mifepristone to interrupt pregnancy up to 63 days (9 weeks) of gestation counted from the first day of the last menstrual period. 1

Side Effects

Vaginal bleeding, cramps, nausea, vomiting, loose stools or diarrhea, headache, muscle weakness, dizziness, hot flashes, backache, dyspnoea, chest pain, palpitations and mild fever . Rarely: uterine rupture, severe hypotension, coronary spasms, with consequent myocardial infarction .

Comparison of misoprostol and gemeprost

The misoprostol has lower cost than gemeprost and also is more stable at room temperature. Gemeprost should be kept frozen until about half an hour before vaginal use. Some studies indicate that severe pain is more common after the use of gemeprost than with misoprostol. 2 3 The misoprostol is formulated to be used orally but appears to be more effective if given vaginally or sublingually. 4


  1. Back to top↑ Bartley J, Brown A, Elton R, Baird DT (October 2001). ‘Double-blind randomized trial of mifepristone in combination with vaginal gemeprost or misoprostol for induction of abortion up to 63 days gestation’ . Human reproduction (Oxford, England) 16 (10): 2098-102. doi : 10.1093 / humrep / 10.16.2098 . PMID  11574498 . Accessed October 29, 2008 .
  2. Back to top↑ Svendsen PF et al. Comparison of gemeprost and vaginal misoprostol in first trimester mifepristone-induced abortion. Contraception, 2005, 72: 28-32.
  3. Back to top↑ Celentano C et al. Oral misoprostol vs. Vaginal gemeprost prior to surgical termination of pregnancy in nulliparae. Acta Obstetrica et Gynecologica Scandinavica, 2004, 83: 764-768
  4. Back to top↑ See p. 20, Advantages and Disadvantages of Misoprostol and Gemeprost, in Frequently Asked Questions About Pharmacological Abortion WHO