Dinoprostone

The prostaglandin E2 or PGE2 is the active ingredient of the drug dinoprostona.

Synonymous

(5Z, 11α, 13E, 15S) -11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid)

Dinoprostone

The natural prostaglandin E2 (PGE2 or PGE2) is the active ingredient in the medicine known as dinoprostone. It has important effects during labor (maturation of the cervix, by softening it, as well as stimulating uterine contractions), it also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that induces fever.

PGE2 also suppresses T-cell receptor signaling and may play a role in resolving inflammation. 1

It is sold under the tradename Cervidil (by Forest Laboratories, Inc. and Propess (by Ferring Pharmaceuticals). This is a controlled release vaginal insert, which is used to help cervical ripening for the birthing process Dinoprostone is A direct vasodilator, relaxes the smooth muscle and inhibits the release of noradrenaline from the sympathetic nerve endings.It does not inhibit platelet aggregation, as if it causes PG 2

Dinoprostone acts by binding and activating the prostaglandin E2 receptor. It was discovered by Bunting, Gryglewski, Moncada and Vane in 1976. An over-regulation has been implicated as a possible etiology of acropaquia

It is also involved in congenital heart diseases dependent on the ductus arteriosus and is used in infusion for the opening of the duct although PGE1 is most commonly used.

Precautions

Uterine scarring; asthma; low blood pressure; heart disease; Adrenal problems; anemia; diabetes; glaucoma; Jaundice (jaundice); Multiparity (twins, triplets, etc.); Heart, lung or liver disease. 3

References

  1. Back to top↑ Jump up ^ Wiemer, AJ; Hegde, S; Gumperz, JE; Huttenlocher, A (1 October 2011). “A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.” Journal of Immunology (Baltimore, Md .: 1950) 187 (7): 3663-70. Doi: 104049 / jimmunol.1100103. PMID 21900181 .
  2. Back to top↑ Pharmacology 2007. Rang, Ritter, Dale, Flower. Churchill Livingstone Elsevier .
  3. Back to top↑ Judiths Hopfer Deglin and April Hazard Vallerand (2006), Davis Drug Guide for Nurses, FA Davis, Philadelphia, Pennsylvania, USA Copyright, 1427 pages .